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  • Asenapine  65576-45-6
Name:Asenapine 65576-45-6
CAS No:65576-45-6

PRODUCT DESCRIPTION


Description

Asenapine (USAN, rINNM and BANM; trade names Saphris (AU, US, RU), Sycrest (EU, UK)) is an atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder by Schering-Plough after its November 19, 2007 merger with Organon International. Development of the drug, through Phase III trials, began while Organon was still a part of Akzo Nobel. Preliminary data indicate that it has minimal anticholinergic and cardiovascular side effects, as well as minimal weight gain. Over 3000 patients have participated in clinical trials of asenapine, and the FDA approved the manufacturer's NDA in August 2009.
It was chemically derived via altering the chemical structure of the tetracyclic (atypical) antidepressant, mianserin.

Basic Info

Chemical Name Asenapine
Synonyms

L-Ascorbic Acid 6-Palmitate;scorbicpalmitate;Vitamin C Palmitate;<36Cl>-trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrole;6-palmitoylascorbic acid;trans-5-Chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz<2,3:6,7>oxepino<4,5-c>pyrrolidine;Collapse

CAS No. 65576-45-6
Molecular Formula C17H16ClNO
Molecular Weight 285.76800
PSA 12.47000
LogP 4.19640

Numbering system

EINECS number 265-829-4

Properties

Appearance & Physical State COA
Density 1.231
Boiling Point 357.9ºC at 760 mmHg
Flash Point 170.2ºC
Refractive Index 1.609

Safety Info

HS Code 2934999090

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